Drug Information

Drug General Information
Drug ID
D0P0TR
Former ID
DIB006496
Drug Name
Meluadrine
Synonyms
Meluadrine tartrate; HSR-81
Drug Type
Small molecular drug
Indication Premature ejaculation [ICD9: 302.75; ICD10:F52.4] Discontinued in Preregistration [545398]
Company
Hokuriku Seiyaku KK
Formula
C12H18ClNO2
Canonical SMILES
C(NC[C@@H](c1c(cc(cc1)O)Cl)O)(C)(C)C
CAS Number
CAS 134865-37-5
PubChem Compound ID
3045414
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Modulator [526451]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545398Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003111)
Ref 526451Effects of meluadrine tartrate and ritodrine hydrochloride on oxytocin-induced uterine contraction, uterine arterial blood flow and maternal cardiovascular function in pregnant goats. Jpn J Pharmacol. 2002 Oct;90(2):107-13.

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