TTD | Drug: D06UKG

Drug General Information
Drug ID	D06UKG
Former ID	DIB003999
Drug Name	LY-377604
Synonyms	Ethanolamine analogs, Lilly; Obesity therapeutics, Lilly; Beta-3 adrenoceptor agonists, Lilly
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Phase 2	[522816]
Company	Eli Lilly & Co
Formula	C31H32N4O4
Canonical SMILES	[nH]1c2c(c3c1cccc3)c(OC[C@H](CNC(Cc1ccc(Oc3ncc(C(=O)N)c<br />c3)cc1)(C)C)O)ccc2
CAS Number	CAS 204592-94-9
PubChem Compound ID	9849699
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[544405]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522816	ClinicalTrials.gov (NCT00993421) A Weight Loss Study in Overweight Men and Women. U.S. National Institutes of Health.
Ref 544405	Combination of a Beta Adrenoceptor Modulator and a Norepinephrine-Serotonin Uptake Inhibitor for the Treatment of Obesity. ACS Med Chem Lett. 2011 August 11; 2(8): 583-586.

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Drug Information