Drug Information

Drug General Information
Drug ID
D01LPX
Former ID
DIB016317
Drug Name
Linotroban
Synonyms
CL-871502; HN-11500
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Discontinued in Phase 2 [545440]
Company
Nycomed AS
Formula
C14H15NO5S2
Canonical SMILES
S(=O)(=O)(OCC(NC(=O)OCc1ccccc1)C(=O)OCC)c1ccc(cc1)C
CAS Number
CAS 120824-80-8
PubChem Compound ID
65940
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [534495]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 545440Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003261)
Ref 534495Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. Arzneimittelforschung. 1997 Sep;47(9):1026-30.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.