Drug Information

Drug General Information
Drug ID
D03UNN
Former ID
DIB010602
Drug Name
L-689560
Drug Type
Small molecular drug
Indication Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] Terminated [467573], [544995]
Company
Merck & Co Inc
Formula
C17H15Cl2N3O3
InChI
InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m1/s1
InChIKey
UCKHICKHGAOGAP-KGLIPLIRSA-N
CAS Number
CAS 139051-78-8
PubChem Compound ID
121918
PubChem Substance ID
14877903, 29302410, 50064393, 57339844, 77249602, 104125349, 104414592, 129348359, 135076595, 137162546, 143117016, 178100909, 178101056, 184594792, 226552645
Target and Pathway
Target(s) NMDA receptor Target Info Modulator [526795]
References
Ref 467573(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4239).
Ref 544995Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001828)
Ref 526795Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes. Mol Pharmacol. 1992 May;41(5):923-30.

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