Drug Information

Drug General Information
Drug ID
D00FMV
Former ID
DNC002640
Drug Name
Putrescine
Drug Type
Small molecular drug
Indication Burns and burn infection [ICD9: 001-139; ICD10:A00-B99] Discontinued in Phase 2 [539518], [547142]
Formula
C4H12N2
InChI
InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
InChIKey
KIDHWZJUCRJVML-UHFFFAOYSA-N
CAS Number
CAS 110-60-1
PubChem Compound ID
1045
PubChem Substance ID
3434, 5825, 108539, 588366, 629781, 826882, 838778, 3132664, 7437577, 7890110, 8143681, 8150940, 10503860, 11111663, 11335891, 11361130, 11364540, 11367102, 11369664, 11372474, 11374072, 11377826, 11408821, 11462102, 11485705, 11489751, 11491013, 11492052, 11495460, 11537956, 15194199, 17436306, 24859702, 24859703, 24893255, 26702290, 26707434, 35229592, 38337057, 46261202, 46391410, 46392188, 46392191, 46506728, 47662300, 47959763, 48259246, 48259247, 49748476, 49895575
Target and Pathway
Target(s) S-adenosylmethioninedecarboxylase proenzyme Target Info Inhibitor [551393]
Ornithine decarboxylase Target Info Inhibitor [551393]
BioCyc Pathway Methionine salvage cycle III
Spermine biosynthesis
Spermidine biosynthesisPWY-46:Putrescine biosynthesis I
KEGG Pathway Cysteine and methionine metabolism
Arginine and proline metabolism
Metabolic pathways
NetPath Pathway EGFR1 Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
Methionine MetabolismPW000037:Spermidine and Spermine Biosynthesis
WikiPathways Metabolism of amino acids and derivatives
References
Ref 539518(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2388).
Ref 547142Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013366)
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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