Drug Information

Drug General Information
Drug ID
D0Y0GG
Former ID
DIB016370
Drug Name
Epanolol
Synonyms
Visacor; TS-704
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Discontinued in Preregistration [544649]
Company
Imperial Chemical Industries Plc
Formula
C20H23N3O4
Canonical SMILES
N#Cc1c(OCC(O)CNCCNC(=O)Cc2ccc(cc2)O)cccc1
CAS Number
CAS 86880-51-5
PubChem Compound ID
72014
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [530320]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544649Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000427)
Ref 530320Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris. Br J Clin Pharmacol. 1990 Mar;29(3):333-7.

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