Drug Information

Drug General Information
Drug ID
D09ALE
Former ID
DIB004159
Drug Name
Enadoline
Synonyms
Enadoline hydrochloride; PD-129290
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 2 [525469], [539017]
Company
Parke-Davis & Co
Formula
C24H32N2O3
InChIKey
JMBYBVLCYODBJQ-HFMPRLQTSA-N
PubChem Compound ID
60768
PubChem Substance ID
7978937, 8187043, 14756836, 14854504, 43118116, 50074386, 50261659, 103316363, 104132519, 104321590, 117567760, 124954353, 128294778, 135047989, 135650230, 137249416, 142304409, 144210744, 163414464, 163849334, 172873091, 178100466, 179149737, 189053426, 198935044, 223541403, 226573299, 252484391
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [525469]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 525469Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999 Mar;80(1-2):383-9.
Ref 539017(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1646).
Ref 525469Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999 Mar;80(1-2):383-9.

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