Drug Information

Drug General Information
Drug ID
D0T6RC
Former ID
DIB015600
Drug Name
Dihydrocodeine
Synonyms
Dihydrocodeine bitartrate; DF 118; Dihydrocodeine (oral); S-8115; Dihydrocodeine (oral), Shionogi; (-)-Dihydrocodeine
Drug Type
Small molecular drug
Indication Cancer pain [ICD9: 140-229, 338,780; ICD10:R52, G89] Phase 4 [522148], [542583]
Company
Mundipharma AG
Formula
C18H23NO3
InChI
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
InChIKey
RBOXVHNMENFORY-DNJOTXNNSA-N
PubChem Compound ID
5284543
PubChem Substance ID
7979086, 11039338, 14751770, 14922962, 39317861, 46506478, 48415896, 49992976, 57359107, 79356041, 96024528, 123090163, 129105931, 134224170, 134975551, 137225019, 142842435, 143309001, 160964796, 175266000, 179116652, 184595582, 223365929, 224980825, 226412911
Target and Pathway
Target(s) Opioid receptor Target Info Modulator [526452]
References
Ref 522148ClinicalTrials.gov (NCT00547885) Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-malignant Pain. U.S. National Institutes of Health.
Ref 542583(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7594).
Ref 526452Affinities of dihydrocodeine and its metabolites to opioid receptors. Pharmacol Toxicol. 2002 Aug;91(2):57-63.

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