Drug Information

Drug General Information
Drug ID
D0T9SJ
Former ID
DIB005008
Drug Name
CEP-4186
Synonyms
CB-1093; CEP-3265; GS-1590; Neurotrophic compounds, Cephalon/LEO Pharma; Neurotrophic factors, Cephalon/LEO Pharma
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Terminated [547043]
Company
LEO Pharma A/S
Canonical SMILES
[C@]12([C@H](CC[C@H]1/C(=C/C=C/1\C(=C)[C@H](C[C@@H](C1)<br />O)O)/CCC2)[C@H](C(C#CCC(O)(CC)CC)OCC)C)C
CAS Number
CAS 167678-65-1
Target and Pathway
Target(s) Vitamin D receptor Target Info Modulator [534675]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 547043Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012493)
Ref 534675Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo. Int J Oncol. 1998 Sep;13(3):421-8.

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