Drug Information

Drug General Information
Drug ID
D0Q9RR
Former ID
DCL000450
Drug Name
AZD0328
Synonyms
AR-R23465XX; AZD-0328; Spiro[1-azabicyclo[2.2.2]octane-8,8'-7-oxa-5-azabicyclo[4.3.0]nona-2,4,10-triene]
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 2 [542672], [547698]
Company
AstraZeneca
Formula
C13H16N2O
InChI
InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
InChIKey
OCKIPDMKGPYYJS-ZDUSSCGKSA-N
PubChem Compound ID
9794392
PubChem Substance ID
14749001, 24104699, 26683777, 44830411, 53834756, 76063335, 81044368, 128788842, 135263116, 140924904, 141812162, 163313113, 163342267, 198960366, 223366030, 223789077, 227667982
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 542672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7697).
Ref 547698Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018503)

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