Drug Information

Drug General Information
Drug ID
D06SBK
Former ID
DIB005197
Drug Name
Atocalcitol
Synonyms
KH-1650
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [547286]
Company
LEO Pharma A/S
Formula
C32H46O4
Canonical SMILES
[C@]12([C@@H](/C(=C/C=C/3\C(=C)[C@H](C[C@@H](C3)O)O)/CC<br />C2)CC[C@H]1[C@H](COCc1cc(C(O)(C)C)ccc1)C)C
CAS Number
CAS 302904-82-1
PubChem Compound ID
70691446
Target and Pathway
Target(s) Vitamin D receptor Target Info Agonist [530202]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 547286Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014844)
Ref 530202Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. IDrugs. 2009 Jun;12(6):381-93.

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