Drug Information

Drug General Information
Drug ID
D0B6EU
Former ID
DIB015793
Drug Name
AS-35
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544897]
Company
Mitsubishi-Tokyo Pharmaceuticals Inc
Formula
C21H20N6O4
Canonical SMILES
n12c(ncc(c1=O)c1nnn[nH]1)c(ccc2)COc1c(c(c(cc1)C(=O)C)O)<br />CCC
CAS Number
CAS 108427-72-1
PubChem Compound ID
130135
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [526815]
Leukotriene CysLT2 receptor Target Info Modulator [526815]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 544897Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001439)
Ref 526815Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58(4):347-55.

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