Drug Information

Drug General Information
Drug ID
D0K1AF
Former ID
DIB002124
Drug Name
A-74273
Synonyms
A-74723
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [544985]
Company
Abbott Laboratories
Formula
C44H74N4O8
Canonical SMILES
C(=O)(N1CCC(CC1)OCOC)[C@@H](O[C@H](C(=O)N[C@H]([C@H](C[<br />C@@H](C(=O)NCCCN1CCOCC1)C(C)C)O)CC1CCCCC1)CCCC)Cc1ccccc<br />1
CAS Number
CAS 130316-95-9
PubChem Compound ID
5483842
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [533789]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544985Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001791)
Ref 533789The orally active renin inhibitor A-74273. In vivo and in vitro morpholine ring metabolism in rats, dogs, and humans. Drug Metab Dispos. 1994 Nov-Dec;22(6):880-8.

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