Drug Information

Drug General Information
Drug ID
D0O5YZ
Former ID
DIB013577
Drug Name
Mepindolol
Synonyms
Mepindolol Bio Tsd; PH-851; Mepindolol, Pharmed/SB
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Approved [551871]
Company
Pharmed Dr Liedtke GmbH
Formula
C30H46N4O8S
Canonical SMILES
c12c([nH]c(c1)C)cccc2OCC(CNC(C)C)O
CAS Number
CAS 23694-81-7
PubChem Compound ID
6917859
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [533373], [544004], [551871]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533373Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol. Arzneimittelforschung. 1986 May;36(5):811-3.
Ref 544004Pindolol--a beta-adrenoceptor blocking drug with partial agonist activity: clinical pharmacological considerations.. Br J Clin Pharmacol. 1982; 13(Suppl 2): 187S-192S.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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