Drug Information

Drug General Information
Drug ID
D0R3MB
Former ID
DNC003663
Drug Name
6-(Benzofuran-2-sulfonyl)-2H-pyridazin-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527771]
Formula
C12H8N2O4S
Canonical SMILES
C1=CC=C2C(=C1)C=C(O2)S(=O)(=O)C3=NNC(=O)C=C3
InChI
1S/C12H8N2O4S/c15-10-5-6-11(14-13-10)19(16,17)12-7-8-3-1-2-4-9(8)18-12/h1-7H,(H,13,15)
InChIKey
RBZSSTPBYFHRSR-UHFFFAOYSA-N
PubChem Compound ID
11807954
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [527771]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

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