Drug Information

Drug General Information
Drug ID
D07UBR
Former ID
DNC006886
Drug Name
Cis-N,5-dibenzyl-6-oxomorpholine-3-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528344]
Formula
C19H20N2O3
Canonical SMILES
C1C(NC(C(=O)O1)CC2=CC=CC=C2)C(=O)NCC3=CC=CC=C3
InChI
1S/C19H20N2O3/c22-18(20-12-15-9-5-2-6-10-15)17-13-24-19(23)16(21-17)11-14-7-3-1-4-8-14/h1-10,16-17,21H,11-13H2,(H,20,22)/t16-,17-/m0/s1
InChIKey
ORMAGLLOPOBCBO-IRXDYDNUSA-N
PubChem Compound ID
44417210
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [528344]
Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Inhibitor [528344]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainmenthsa04010:MAPK signaling pathway
Circadian entrainment
Type II diabetes mellitus
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growthWP1866:NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin Cells
References
Ref 528344Bioorg Med Chem Lett. 2006 Oct 1;16(19):5244-8. Epub 2006 Jul 28.Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.
Ref 528344Bioorg Med Chem Lett. 2006 Oct 1;16(19):5244-8. Epub 2006 Jul 28.Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.

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