Drug Information

Drug General Information
Drug ID
D0R7VT
Former ID
DNC005950
Drug Name
4-(1H-indol-1-ylsulfonyl)benzenamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527760]
Formula
C14H12N2O2S
Canonical SMILES
C1=CC=C2C(=C1)C=CN2S(=O)(=O)C3=CC=C(C=C3)N
InChI
1S/C14H12N2O2S/c15-12-5-7-13(8-6-12)19(17,18)16-10-9-11-3-1-2-4-14(11)16/h1-10H,15H2
InChIKey
FLNRELDLHZADER-UHFFFAOYSA-N
PubChem Compound ID
44263491
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527760]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527760Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.
Ref 527760Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.

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