Drug Information

Drug General Information
Drug ID
D00GTC
Former ID
DIB018886
Drug Name
AS1269574
Synonyms
AS 1269574; AS-1269574
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540630]
Formula
C13H14BrN3O
InChI
InChI=1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
InChIKey
DUKPGOOUJNUIOI-UHFFFAOYSA-N
PubChem Compound ID
5332859
PubChem Substance ID
8042775, 10560924, 11571771, 39305441, 52560170, 89188351, 92166734, 114147996, 124463909, 125333856, 136921213, 136970102, 169116732, 170474661, 173897520, 178100853, 196372355, 226719722, 244237346, 250136898, 252157849
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [531137]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 540630(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4027).
Ref 531137Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010 Sep 24;400(3):437-41.

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