Drug Information

Drug General Information
Drug ID
D0V0AW
Former ID
DIB021025
Drug Name
TC-2559
Synonyms
TC2559
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540602]
Formula
C12H18N2O
InChI
InChI=1S/C12H18N2O/c1-3-15-12-8-11(9-14-10-12)6-4-5-7-13-2/h4,6,8-10,13H,3,5,7H2,1-2H3/b6-4+
InChIKey
HFZDMKMXPGRKCK-GQCTYLIASA-N
PubChem Compound ID
9823180
PubChem Substance ID
14797618, 24126268, 44859137, 50112983, 77644022, 85788223, 96099858, 138433311, 163315782, 163346929, 178100813, 212558924, 226553552, 226922287
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-2 chain Target Info Agonist [526677]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic Neurons
References
Ref 540602(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3987).
Ref 526677The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology. 2003 Sep;45(3):334-44.

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