Drug Information

Drug General Information
Drug ID
D01OIV
Former ID
DIB021008
Drug Name
T-0509
Synonyms
RP333
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540773]
Formula
C18H23NO5
InChI
InChI=1S/C18H23NO5/c1-23-17-6-3-12(9-18(17)24-2)7-8-19-11-16(22)13-4-5-14(20)15(21)10-13/h3-6,9-10,16,19-22H,7-8,11H2,1-2H3
InChIKey
DIPGFXJERHNAQQ-UHFFFAOYSA-N
PubChem Compound ID
173382
PubChem Substance ID
10257844, 16829708, 33497748, 78919890, 85209324, 113473776, 127740087, 135192146, 135651221, 229684913
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [534301]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540773(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 533).
Ref 534301Molecular characterization of pharmacological properties of T-0509 for beta-adrenoceptors. Eur J Pharmacol. 1996 Nov 21;315(3):363-7.

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