Drug Information

Drug General Information
Drug ID
D0N5CH
Former ID
DIB020035
Drug Name
ICA-27243
Synonyms
ICA 27243; ICA27243
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542645]
Formula
C12H7ClF2N2O
InChI
InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
InChIKey
GDGUOCFTHNGPBK-UHFFFAOYSA-N
PubChem Compound ID
9903497
PubChem Substance ID
14872594, 24185513, 45975168, 57373736, 74603414, 87350303, 87457385, 103562093, 117688381, 134225009, 138984654, 163369073, 172649959, 187072020, 198953729, 218903010, 223366002, 225374601, 226699778, 245792781
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 2 Target Info Activator [530361]
KEGG Pathway Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Voltage gated Potassium channels
Interaction between L1 and Ankyrins
WikiPathways Potassium Channels
L1CAM interactions
References
Ref 542645(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7667).
Ref 530361The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42.

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