Drug Information

Drug General Information
Drug ID
D0T4WL
Former ID
DNC013586
Drug Name
1-hydroxy-3-phenylurea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529488]
Formula
C7H8N2O2
Canonical SMILES
C1=CC=C(C=C1)NC(=O)NO
InChI
1S/C7H8N2O2/c10-7(9-11)8-6-4-2-1-3-5-6/h1-5,11H,(H2,8,9,10)
InChIKey
AAVSQBMWOCNSDL-UHFFFAOYSA-N
PubChem Compound ID
81786
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [529488]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 529488Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.
Ref 529488Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

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