Drug Information

Drug General Information
Drug ID
D0Q1ZC
Former ID
DNC003989
Drug Name
3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525940]
Formula
C20H22N2
Canonical SMILES
CN1CCC(CC1)C2=C(NC3=CC=CC=C32)C4=CC=CC=C4
InChI
1S/C20H22N2/c1-22-13-11-15(12-14-22)19-17-9-5-6-10-18(17)21-20(19)16-7-3-2-4-8-16/h2-10,15,21H,11-14H2,1H3
InChIKey
UBCVYEFSXHCFPK-UHFFFAOYSA-N
PubChem Compound ID
9838958
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [525940]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 525940Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3.3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.
Ref 525940Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3.3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.

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