TTD | Drug: D0K6MI

Drug General Information
Drug ID	D0K6MI
Former ID	DIB018156
Drug Name	[125I]ICYP
Synonyms	[125I]iodocyanopindolol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540989]
Formula	C15H18IN3O2
InChI	InChI=1S/C15H18IN3O2/c1-9(2)18-7-10(20)8-21-13-5-3-4-11-14(13)15(16)12(6-17)19-11/h3-5,9-10,18-20H,7-8H2,1-2H3/i16-2
InChIKey	WGSPBWSPJOBKNT-RFLHHMENSA-N
PubChem Compound ID	73754996
PubChem Substance ID	135651110, 135651111
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[526944]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540989	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 562).
Ref 526944	Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors. Eur J Pharmacol. 2004 Jan 26;484(2-3):323-31.

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Drug Information