Drug Information

Drug General Information
Drug ID
D07DCN
Former ID
DNC006784
Drug Name
4-(3-benzenesulfonamidophenyl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528373]
Formula
C16H19N3O2S
Canonical SMILES
C1CN(CCN1)C2=CC(=CC=C2)NS(=O)(=O)C3=CC=CC=C3
InChI
1S/C16H19N3O2S/c20-22(21,16-7-2-1-3-8-16)18-14-5-4-6-15(13-14)19-11-9-17-10-12-19/h1-8,13,17-18H,9-12H2
InChIKey
KUAATZXIILUWMF-UHFFFAOYSA-N
PubChem Compound ID
11849196
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [528373]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

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