Drug Information

Drug General Information
Drug ID
D0H4MO
Former ID
DIB020514
Drug Name
NE58027
Synonyms
NE 58027
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540144]
Formula
C7H17NO7P2
InChI
InChI=1S/C7H17NO7P2/c9-7(16(10,11)12,17(13,14)15)5-6-3-1-2-4-8-6/h6,8-9H,1-5H2,(H2,10,11,12)(H2,13,14,15)
InChIKey
GKUBJNUBGKBXKR-UHFFFAOYSA-N
PubChem Compound ID
14231197
PubChem Substance ID
31640182, 54080544, 103565847, 127968125, 135650701, 160852199, 234186988
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529362]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540144(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3154).
Ref 529362J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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