Drug Information

Drug General Information
Drug ID
D0L1NQ
Former ID
DNC009383
Drug Name
3-Phenylquinoline-8-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529894]
Formula
C16H12N2O
Canonical SMILES
C1=CC=C(C=C1)C2=CN=C3C(=C2)C=CC=C3C(=O)N
InChI
1S/C16H12N2O/c17-16(19)14-8-4-7-12-9-13(10-18-15(12)14)11-5-2-1-3-6-11/h1-10H,(H2,17,19)
InChIKey
DFGJDJRADWQKAW-UHFFFAOYSA-N
PubChem Compound ID
25208596
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529894]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

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