Drug Information

Drug General Information
Drug ID
D06JMV
Former ID
DNC012882
Drug Name
PB-27
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527568]
Formula
C26H25N7O2S
Canonical SMILES
CN1C=NC=C1CN2CC(CC3=C2C=CC(=C3)C#N)N(CC4=CC=CC=N4)S(=O)<br />(=O)C5=CC=CC=N5
InChI
1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
InChIKey
GQLZRVHYGCXHSR-UHFFFAOYSA-N
PubChem Compound ID
11271978
Target and Pathway
Target(s) Farnesyltransferase Target Info Inhibitor [527568]
Protein farnesyltransferase beta subunit Target Info Inhibitor [527568]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 527568J Med Chem. 2005 Jun 2;48(11):3704-13.Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Ref 527568J Med Chem. 2005 Jun 2;48(11):3704-13.Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.