Drug Information

Drug General Information
Drug ID
D03LRQ
Former ID
DNC014204
Drug Name
2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530758]
Formula
C13H11NO3
Canonical SMILES
C1=CC=C(C=C1)C(=O)C2=CN(C=C2)CC(=O)O
InChI
1S/C13H11NO3/c15-12(16)9-14-7-6-11(8-14)13(17)10-4-2-1-3-5-10/h1-8H,9H2,(H,15,16)
InChIKey
NFEXRSVGIRNYEZ-UHFFFAOYSA-N
PubChem Compound ID
10398922
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [530758]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 530758Bioorg Med Chem. 2010 Mar 15;18(6):2107-14. Epub 2010 Feb 11.Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case ofbioisosterism between a carboxylic acid moiety and that of a tetrazole.
Ref 530758Bioorg Med Chem. 2010 Mar 15;18(6):2107-14. Epub 2010 Feb 11.Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case ofbioisosterism between a carboxylic acid moiety and that of a tetrazole.

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