Drug Information

Drug General Information
Drug ID
D0Y1PG
Former ID
DNC000347
Drug Name
BRL 37344
Drug Type
Small molecular drug
Indication Discovery agent Terminated [541013], [546206]
Formula
C19H22ClNO4
InChI
InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
InChIKey
ZGGNJJJYUVRADP-ACJLOTCBSA-N
PubChem Compound ID
9841972
PubChem Substance ID
14803601, 24139987, 44940048, 80092470, 103194009, 103916442, 134341189, 135650024, 140102674, 177748588, 198982358, 226644355, 243023543, 249817747, 249819800
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [537970]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 541013(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 567).
Ref 546206Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006890)
Ref 537970Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34.

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