Drug Information

Drug General Information
Drug ID
D07AGU
Former ID
DNC009382
Drug Name
Quinoline-8-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529894]
Formula
C10H8N2O
Canonical SMILES
C1=CC2=C(C(=C1)C(=O)N)N=CC=C2
InChI
1S/C10H8N2O/c11-10(13)8-5-1-3-7-4-2-6-12-9(7)8/h1-6H,(H2,11,13)
InChIKey
HPQRQAOVNXWEEQ-UHFFFAOYSA-N
PubChem Compound ID
150664
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529894]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Ref 529894J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

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