Drug Information

Drug General Information
Drug ID
D05WFQ
Former ID
DIB020565
Drug Name
norzotepine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530783]
Formula
C17H16ClNOS
InChI
InChI=1S/C17H16ClNOS/c1-19-8-9-20-15-10-12-4-2-3-5-16(12)21-17-7-6-13(18)11-14(15)17/h2-7,10-11,19H,8-9H2,1H3
InChIKey
OVVBIIBBRZVPAL-UHFFFAOYSA-N
PubChem Compound ID
10041551
PubChem Substance ID
15024533, 22465550, 44158608, 79663619, 134222735, 140154830, 187051838, 232784759, 248180242
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530783]
Sodium-dependent serotonin transporter Target Info Inhibitor [530783]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 530783Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81.
Ref 530783Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81.

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