Drug Information

Drug General Information
Drug ID
D02EHY
Former ID
DIB018558
Drug Name
2MD
Synonyms
VDZ; 2-methylene-19-nor-(20S)-1 alpha,25-dihydroxy-vitamin D3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539821]
Formula
C27H44O3
InChI
InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)22-12-13-23-21(9-7-15-27(22,23)5)11-10-20-16-24(28)19(2)25(29)17-20/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b21-11+/t18-,22+,23-,24+,25+,27+/m0/s1
InChIKey
UHMPCVGLSKFXHR-NAQZCRMNSA-N
PubChem Compound ID
5289549
PubChem Substance ID
7891051, 11041577, 14715431, 14758023, 14831432, 39321715, 57359287, 79559732, 103718124, 113874582, 135651400, 137681105, 160867517, 179662856, 208011966, 230773318, 243217789
Target and Pathway
Target(s) Vitamin D receptor Target Info Agonist [534740]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 539821(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2776).
Ref 534740New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. J Med Chem. 1998 Nov 5;41(23):4662-74.

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