Drug Information

Drug General Information
Drug ID
D0KH5R
Former ID
DIB020900
Drug Name
SB 215505
Synonyms
SB-215505; SB-215,505
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539200]
Formula
C19H16ClN3O
InChI
InChI=1S/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-2-5-16-14(17)4-3-8-21-16/h2-6,8,10-11H,7,9H2,1H3,(H,22,24)
InChIKey
HOVMHIRTZYQSKM-UHFFFAOYSA-N
PubChem Compound ID
10449757
PubChem Substance ID
15471136, 22785537, 40577394, 74681805, 85224652, 128091820, 134222955, 135650987, 136351959, 160677108, 227395270, 252156033, 252813981
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [525458]
5-hydroxytryptamine 2B receptor Target Info Antagonist [525458]
5-hydroxytryptamine 2C receptor Target Info Antagonist [525458]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539200(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 190).
Ref 525458Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4.

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