Drug Information

Drug General Information
Drug ID
D0Q6UT
Former ID
DNC014394
Drug Name
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530900]
Formula
C8H12N2OS
Canonical SMILES
C1CCC(CC1)C2=NNC(=S)O2
InChI
1S/C8H12N2OS/c12-8-10-9-7(11-8)6-4-2-1-3-5-6/h6H,1-5H2,(H,10,12)
InChIKey
ONBUSMDUKULCRC-UHFFFAOYSA-N
PubChem Compound ID
3803233
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [530900]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

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