Drug Information

Drug General Information
Drug ID
D0W7XH
Former ID
DNC002340
Drug Name
DR2313
Drug Type
Small molecular drug
Indication Permanent and transient stroke [ICD9: 434.91, 435.9; ICD10:G45.9, I61-I63] Investigative [536077]
Formula
C8H10N2OS
Canonical SMILES
CC1=NC(=O)C2=C(N1)CCSC2
InChI
1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChIKey
HRYKZAKEAVZGJD-UHFFFAOYSA-N
PubChem Compound ID
10219702
PubChem Substance ID
15219719, 22608712, 26759382, 40334200, 47211760, 50112881, 57374403, 77559784, 85788202, 99238636, 99246552, 99444148, 103652092, 104120157, 118845236, 121503098, 123392404, 125346955, 126576933, 126629926, 126734873, 132573658, 134964469, 160829200, 160968747, 162023498, 163093889, 163389609, 163687471, 164831363, 165239256, 170482091, 174555355, 202544456, 206247125, 211786564, 218190634, 223573625, 226746836, 240064958, 248372641, 252156560, 252160010, 252218095
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [536077]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 536077Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.
Ref 536077Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.

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