Drug Information

Drug General Information
Drug ID
D0S7YD
Former ID
DIB020516
Drug Name
NE58062
Synonyms
NE 58062
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540150]
Formula
C7H16N2O6P2
InChI
InChI=1S/C7H16N2O6P2/c1-5-3-2-4-8-6(5)9-7(16(10,11)12)17(13,14)15/h5,7H,2-4H2,1H3,(H,8,9)(H2,10,11,12)(H2,13,14,15)
InChIKey
XUCBNFJYKWKAMN-UHFFFAOYSA-N
PubChem Compound ID
15230201
PubChem Substance ID
103565749, 135650703
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529362]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540150(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3166).
Ref 529362J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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