Drug Information

Drug General Information
Drug ID
D08QWQ
Former ID
DIB018003
Drug Name
bimatoprost (free acid form)
Synonyms
17-phenyl-omega-trinor-PGF2alpha
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Clinical trial [539256]
Formula
C23H32O5
InChI
InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,21-,22+/m0/s1
InChIKey
YFHHIZGZVLHBQZ-KDACTHKWSA-N
PubChem Compound ID
5283081
PubChem Substance ID
4266015, 11038736, 14878437, 39316497, 57358841, 74729648, 113859036, 135649996, 140173868, 164174654, 179656243, 198963020, 224677461, 228580141, 241067653, 252377743, 252464510
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Agonist [525853]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539256(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1959).
Ref 525853Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol. 2000 Aug;130(8):1933-43.

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