Drug Information

Drug General Information
Drug ID
D0D2WX
Former ID
DNCL003573
Drug Name
1614235 + 2330672
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [549464]
Company
GlaxoSmithKline
Formula
C21H28NO3+
PubChem Compound ID
1614235
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Modulator [543973]
Ileal bile acid transfer Target Info Modulator [543982]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorptionhsa04976:Bile secretion
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-159418:Recycling of bile acids and salts
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP1788:Bile acid and bile salt metabolism
References
Ref 549464Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037723)
Ref 543973(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 915).
Ref 543982(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960).

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