Drug Information

Drug General Information
Drug ID
D03NXZ
Former ID
DIB019666
Drug Name
CV-1674
Synonyms
2-(4-methoxyphenyl)adenosine; CV 1674; NSC 310669; CV1674
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467525]
Formula
C17H19N5O5
InChI
InChI=1S/C17H19N5O5/c1-26-9-4-2-8(3-5-9)15-20-14(18)11-16(21-15)22(7-19-11)17-13(25)12(24)10(6-23)27-17/h2-5,7,10,12-13,17,23-25H,6H2,1H3,(H2,18,20,21)
InChIKey
VKSRAKNPXOTFAX-UHFFFAOYSA-N
PubChem Compound ID
100022
PubChem Substance ID
455261, 6733181, 8141105, 10231006, 10320080, 11407070, 44430187, 57337049, 75258882, 85209042, 103104829, 104360456, 117523113, 135056495, 135650140, 163159511, 242084365
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Agonist [534821]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467525(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 419).
Ref 534821Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75.

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