Drug Information

Drug General Information
Drug ID
D0X6LZ
Former ID
DIB018590
Drug Name
3-chlorotyrosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468178]
Formula
C9H10ClNO3
InChI
InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)
InChIKey
ACWBBAGYTKWBCD-UHFFFAOYSA-N
PubChem Compound ID
119226
PubChem Substance ID
6008011, 10238398, 14818878, 29300158, 50065134, 57339388, 75612601, 83584729, 103129672, 104407834, 117461199, 125357060, 125536908, 125658372, 126524197, 131325289, 135074455, 136159797, 137323677, 138733030, 145470084, 162138098, 163059354, 165354563, 178101807, 206255106, 226521326, 250135365
Target and Pathway
Target(s) Tyrosine 3-monooxygenase Target Info Inhibitor [543389]
BioCyc Pathway Catecholamine biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse
Prolactin signaling pathway
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Pathway Interaction Database ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Alpha-synuclein signaling
PathWhiz Pathway Catecholamine Biosynthesis
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic Neurons
References
Ref 468178(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5114).
Ref 543389(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).

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