Drug Information

Drug General Information
Drug ID
D0H5EP
Former ID
DNC004865
Drug Name
1-Benzenesulfonyl-3-piperidin-4-yl-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527339]
Formula
C19H20N2O2S
Canonical SMILES
C1CNCCC1C2=CN(C3=CC=CC=C32)S(=O)(=O)C4=CC=CC=C4
InChI
1S/C19H20N2O2S/c22-24(23,16-6-2-1-3-7-16)21-14-18(15-10-12-20-13-11-15)17-8-4-5-9-19(17)21/h1-9,14-15,20H,10-13H2
InChIKey
CACLUIQWYMWMBO-UHFFFAOYSA-N
PubChem Compound ID
44388931
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527339]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527339Bioorg Med Chem Lett. 2005 Jan 17;15(2):379-83.N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.
Ref 527339Bioorg Med Chem Lett. 2005 Jan 17;15(2):379-83.N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.

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