Drug Information

Drug General Information
Drug ID
D06CED
Former ID
DNC010812
Drug Name
3'-(5-Chloro-2-thienyl)biphenyl-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530868]
Formula
C16H11ClOS
Canonical SMILES
C1=CC(=CC(=C1)C2=CC=C(S2)Cl)C3=CC(=CC=C3)O
InChI
1S/C16H11ClOS/c17-16-8-7-15(19-16)13-5-1-3-11(9-13)12-4-2-6-14(18)10-12/h1-10,18H
InChIKey
IBTNRYGKAUWUJS-UHFFFAOYSA-N
PubChem Compound ID
46844318
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [530868]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

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