Drug Information

Drug General Information
Drug ID
D0C6PS
Former ID
DAP001301
Drug Name
Muromonab
Indication Organ rejection [ICD9: 279.5, 996; ICD10:D89.8, T86] Approved [536361]
Therapeutic Class
Immunomodulatory Agents
Formula
C6460H9946N1720O2043S56
CAS Number
CAS 140608-64-6
Target and Pathway
Target(s) T-cell surface glycoprotein CD3 epsilon chain Target Info Binder [535879]
KEGG Pathway Hematopoietic cell lineage
T cell receptor signaling pathway
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infection
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway T cell activation
Pathway Interaction Database TCR signaling in na&#xef
IL12-mediated signaling events
TCR signaling in na&#xef
CXCR4-mediated signaling events
IL23-mediated signaling events
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
WikiPathways TCR Signaling Pathway
TCR signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Costimulation by the CD28 family
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535879Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35.

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