Drug Information

Drug General Information
Drug ID
D05RXG
Former ID
DNC010269
Drug Name
5-amino-3,4-dihydroisoquinolin-1(2H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530584]
Formula
C9H10N2O
Canonical SMILES
C1CNC(=O)C2=C1C(=CC=C2)N
InChI
1S/C9H10N2O/c10-8-3-1-2-7-6(8)4-5-11-9(7)12/h1-3H,4-5,10H2,(H,11,12)
InChIKey
RTPKPVYTPRJRBY-UHFFFAOYSA-N
PubChem Compound ID
18369509
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [530584]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 530584Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Ref 530584Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

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