Drug Information

Drug General Information
Drug ID
D0OW4W
Former ID
DNC013857
Drug Name
4-(4-Chlorophenyl)-5-p-tolylisothiazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529881]
Formula
C16H12ClNS
Canonical SMILES
CC1=CC=C(C=C1)C2=C(C=NS2)C3=CC=C(C=C3)Cl
InChI
1S/C16H12ClNS/c1-11-2-4-13(5-3-11)16-15(10-18-19-16)12-6-8-14(17)9-7-12/h2-10H,1H3
InChIKey
YLLFNDIXMCYHET-UHFFFAOYSA-N
PubChem Compound ID
44564455
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [529881]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 529881Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Ref 529881Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.