Drug Information

Drug General Information
Drug ID
D0X7JR
Former ID
DAP001349
Drug Name
Eflornithine
Synonyms
Dfmo; Difluoromethylornithine; Difluromethylornithine; Eflornithinum; Eflornitina; Ornidyl; Vaniqa; DFMO HCl; DFMO hydrochloride; DFMO hydrochloride hydrate; EFLORNITHINE HYDROCHLORIDE; Eflornithine HCl; Eflornithine hydrochloride [USAN]; Eflornithine hydrochloride hydrate; Eflornithine hydrochloride monohydrate; Eflornithinum [Latin]; Eflornitina [Spanish]; BMS 203522; MDL 71782; RMI 71782; Alpha-DFMO HCl; Alpha-Difluoromethylornithine; Alpha-Difluoromethylornithine hydrochloride; CPP-1X;DFMO (growth regulator); Eflornithine (INN); Eflornithine [INN:BAN]; Eflornithine hydrochloride (USAN); MDL 71,782 A; MDL-71782A; N-Difluoromethylornithine; Ornidyl (TN); RMI-71782; DL-alpha-Difluoromethylornithine; DL-alpha-Difluoromethylornithine hydrochloride; DL-alpha-Difluoromethylornithine hydrochloride hydrate; D,L-alpha-Difluoromethylornithine; D,L-alpha-Difluoromethylornithine hydrochloride; DL-alpha-(Difluoromethyl)ornithine; DL-alpha-Difluoromethylornithine, Hydrochloride; Alpha-(Difluoromethyl)-DL-ornithine; DL-.alpha.-Difluoromethylornithine; Alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid; Ornithine, 2-(difluoromethyl)-, monohydrochloride; DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride; DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate; 2,5-diamino-2-(difluoromethyl)pentanoic acid; 2,5-diamino-2-(difluoromethyl)pentanoic acid hydrate hydrochloride; 2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride; 2-(Difluoromethyl)-DL-ornithine; 2-(Difluoromethyl)-DL-ornithine HCl; 2-(Difluoromethyl)-DL-ornithine hydrochloride; 2-(Difluoromethyl)-DL-ornithine monohydrochloride; 2-(Difluoromethyl)-DL-ornithine monohydrochloride, monohydrate; 2-(Difluoromethyl)-DL-ornithine monohydrochloride.monohydrate; 2-(Difluoromethyl)ornithine; 2-(Difluoromethyl)ornithine hydrochloride hydrate
Drug Type
Small molecular drug
Indication African trypanosomiasis [ICD9: 86.5; ICD10:B56] Approved [468237], [536135]
Therapeutic Class
Anticancer Agents
Company
Sanofi-Aventis
Formula
C6H12F2N2O2
InChI
InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
InChIKey
VLCYCQAOQCDTCN-UHFFFAOYSA-N
CAS Number
CAS 70052-12-9
PubChem Compound ID
3009
PubChem Substance ID
10198, 575150, 597889, 5340424, 7979149, 8151916, 15195195, 26697290, 29222157, 47736604, 48259361, 48413613, 48415938, 49857314, 50068858, 50111043, 57321552, 75030139, 90341137, 96024579, 103937549, 104302261, 123094710, 123121561, 124749707, 124879830, 125675814, 126666031, 126670951, 126685284, 129490554, 132563807, 134338563, 134339956, 135010753, 136342494, 137006071, 142212859, 162178731, 162221551, 162356694, 163134100, 164814590, 164823944, 171578146, 174006789, 178101866, 179117032, 184547857, 184605807
ChEBI ID
ChEBI:41948
SuperDrug ATC ID
D11AX16; P01CX03
SuperDrug CAS ID
cas=070052129
Target and Pathway
Target(s) Ornithine decarboxylase Target Info Inhibitor [537732]
BioCyc Pathway Putrescine biosynthesis I
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
References
Ref 468237(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5176).
Ref 536135Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 537732Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.

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