Drug Information

Drug General Information
Drug ID
D01JJH
Former ID
DIB018080
Drug Name
(3R,4S)-293B
Synonyms
LS-185874; chromanol 239B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526219]
Formula
C15H20N2O4S
InChI
InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChIKey
HVSJHHXUORMCGK-UONOGXRCSA-N
PubChem Compound ID
121846
PubChem Substance ID
854065, 10239832, 14924034, 15396661, 29302351, 50069631, 52629458, 53789183, 53801037, 57339807, 85788658, 91746267, 103356834, 104001800, 104414418, 128120056, 135077955, 152133974, 162023020, 162248376, 187071958, 223442440, 230235373, 241182460, 252160027
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 1 Target Info Blocker (channel blocker) [526219]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathway
References
Ref 526219A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54.
Ref 526219A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54.

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