Drug Information

Drug General Information
Drug ID
D0Q8TK
Former ID
DNC013539
Drug Name
1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529156]
Formula
C13H10N2O2S
Canonical SMILES
C1=CC(=CC=C1C#CC2=CC=NC=C2)S(=O)(=O)N
InChI
1S/C13H10N2O2S/c14-18(16,17)13-5-3-11(4-6-13)1-2-12-7-9-15-10-8-12/h3-10H,(H2,14,16,17)
InChIKey
WAURLAKEIUZSMJ-UHFFFAOYSA-N
PubChem Compound ID
44452472
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [529156]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 529156Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. Epub 2007 Nov 5.Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.
Ref 529156Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. Epub 2007 Nov 5.Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.

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