Drug Information

Drug General Information
Drug ID
D00YNI
Former ID
DIB020150
Drug Name
L-(cis)-diltiazem
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539490]
Formula
C22H26N2O4S
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
InChIKey
HSUGRBWQSSZJOP-LEWJYISDSA-N
PubChem Compound ID
198107
PubChem Substance ID
10262671, 11111056, 11112730, 33517831, 47959865, 50100215, 50111374, 50855581, 57399045, 85788023, 92309773, 99300687, 113466770, 124882575, 128108063, 135650511, 135916535, 143078326, 223447514, 226972223, 242206174
Target and Pathway
Target(s) CNGA1 Target Info Blocker (channel blocker) [533691]
Cav1.4 Target Info Inhibitor (gating inhibitor) [526945]
CNGA2 Target Info Blocker (channel blocker) [528435]
CNGA3 Target Info Inhibitor [543807]
Cyclic nucleotide-gated channel beta-3 (CNGB3) Target Info Blocker (channel blocker) [525687]
KEGG Pathway cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Pathway Interaction Database Visual signal transduction: Cones
References
Ref 539490(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2349).
Ref 525687Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32.
Ref 526945Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13.
Ref 528435Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
Ref 533691A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7.
Ref 543807(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396).

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